Utility of MRI Techniques in Prediction of TBI Outcome

Investigators: Robin Hanks, PhD; Scott Millis, PhD; Randall Benson, MD; Mark Haacke, PhD

The objective of this study is develop multivariable imaging models, which improve the prediction of neurobehavioral and functional outcomes at two key time points—discharge from inpatient hospitalization and one year post injury. It will also examine the depth of lesion models, which suggests that the deeper the lesion the greater the disability. People with TBI who are concurrently admitted to RIM’s TBI inpatient rehabilitation service and who meet the safety standards for neuroimaging will be scanned using three newly developed neuroimaging techniques: Susceptibility Weighted Imaging (SWI), Diffusion Tensor Imaging (DTI), and Magnetic Resonance Spectroscopy Imaging (MRSI). Neuroimaging data will only be collected during the inpatient rehabilitation stay, but neuropsychological and functional outcome data will be collected at the end of their inpatient rehabilitation stay and at 1 year follow-up.